The screwworm, a parasitic fly larvae, has been a significant threat to the cattle industry for decades. Recently, a new world screwworm outbreak has been reported, affecting several countries and posing a risk to human health. The screwworm infestation can cause significant economic losses to the cattle industry, as well as harm to human health. The larvae of the screwworm fly can infect humans, causing a condition known as myiasis, which can lead to serious health complications. The outbreak has been reported in countries such as the United States, Australia, and Brazil, with cases of human infection also being reported. The screwworm is typically found in warm and humid climates, and its spread can be facilitated by human activity, such as trade and travel. The cattle industry is taking measures to control the outbreak, including the use of insecticides and vaccines. However, more needs to be done to prevent the spread of the screwworm and to protect human health. The World Health Organization (WHO) and other international organizations are working to raise awareness about the risks associated with the screwworm and to provide guidance on how to prevent and control the outbreak. In addition to the economic and health impacts, the screwworm outbreak also has significant environmental implications. The use of insecticides to control the outbreak can harm non-target species, such as bees and other pollinators, and can also contaminate soil and water. Furthermore, the screwworm outbreak highlights the need for improved surveillance and monitoring of animal health, as well as the importance of international cooperation in preventing and controlling the spread of diseases. The cattle industry is a significant contributor to the global economy, and the screwworm outbreak has the potential to disrupt trade and commerce. The outbreak also highlights the need for increased investment in animal health research and development, as well as the importance of public-private partnerships in addressing global health challenges. In conclusion, the new world screwworm outbreak is a significant threat to the cattle industry and human health, and requires a coordinated and sustained response from governments, industry, and international organizations. The use of innovative technologies, such as genetic engineering and biotechnology, may also play a role in controlling the outbreak and preventing future occurrences. Moreover, the screwworm outbreak underscores the importance of a One Health approach, which recognizes the interconnectedness of human, animal, and environmental health. By working together and adopting a comprehensive and integrated approach, we can mitigate the impacts of the screwworm outbreak and prevent future occurrences. The screwworm outbreak is a wake-up call for the global community to take action and address the significant challenges posed by this parasitic fly larvae. It is essential to raise awareness about the risks associated with the screwworm and to promote a culture of prevention and control. The cattle industry, governments, and international organizations must work together to develop and implement effective strategies to prevent and control the spread of the screwworm. This includes improving surveillance and monitoring, developing and using effective vaccines and insecticides, and promoting good animal health practices. Additionally, it is crucial to address the environmental implications of the screwworm outbreak and to develop sustainable solutions that minimize harm to non-target species and the environment. The screwworm outbreak is a complex and multifaceted challenge that requires a comprehensive and integrated response. By working together and adopting a One Health approach, we can mitigate the impacts of the outbreak and prevent future occurrences, ultimately protecting the cattle industry, human health, and the environment.